MLS
| # | Jugador | Equipo | Goles | Penal |
|---|---|---|---|---|
| 1 | Lionel Messi |  Miami | 25 | 1 |
| 2 | Petar Musa |  Dallas | 20 | 4 |
| 3 | Milan Iloski |  Philadelphia | 19 | 5 |
| 4 | Rafael Navarro |  Colorado | 18 | 4 |
| 5 | Brian White |  Vancouver | 17 | 1 |
| 5 | Denis Bouanga |  LAFC | 17 | 1 |
| 5 | Kelvin Yeboah |  Minnesota | 17 | 3 |
| 5 | Kévin Denkey |  Cincinnati | 17 | 3 |
| 5 | Sam Surridge |  Nashville | 17 | 3 |
| 10 | Hany Mukhtar | Nashville | 16 | |
| 10 | Preston Judd |  San Jose | 16 | |
| 10 | Guilherme Augusto |  Houston | 16 | 1 |
| 10 | Tai Baribo |  D.C. United | 16 | 5 |
| 14 | Luis Suárez | Miami | 15 | 2 |
| 14 | Nicolás Fernández |  NYCFC | 15 | 4 |
| 14 | Martín Ojeda |  Orlando | 15 | 5 |
| 14 | Prince Owusu |  CF Montréal | 15 | 6 |
| 18 | Evander | Cincinnati | 14 | 3 |
| 19 | Idan Toklomati |  Charlotte | 13 | |
| 19 | Hugo Cuypers |  Chicago | 13 | 2 |
| 19 | Anders Dreyer |  San Diego | 13 | 6 |
| 22 | Antoine Griezmann | Orlando | 12 | |
| 22 | Bruno Damiani | Philadelphia | 12 | |
| 22 | Dejan Joveljic |  Kansas City | 12 | |
| 22 | Sergi Solans |  Salt Lake | 12 | |
| 22 | Marcus Ingvartsen | San Diego | 12 | 1 |
| 22 | Pep Biel | Charlotte | 12 | 2 |
| 22 | Carles Gil |  New England | 12 | 6 |
| 29 | Julian Hall |  Red Bull NY | 11 | |
| 29 | Maren Haile-Selassie | Chicago | 11 | |
| 31 | Logan Farrington | Dallas | 10 | 1 |
| 32 | Christian Ramírez |  Austin | 9 | |
| 32 | Dor Turgeman | New England | 9 | |
| 32 | Germán Berterame | Miami | 9 | |
| 32 | João Klauss |  LA Galaxy | 9 | |
| 32 | Kevin Kelsy |  Portland | 9 | |
| 32 | Simon Becher |  St. Louis | 9 | |
| 32 | Son Heung-Min | LAFC | 9 | |
| 32 | Tom Barlow | Cincinnati | 9 | |
| 32 | Thomas Müller | Vancouver | 9 | 4 |
| 41 | Anthony Markanich | Minnesota | 8 | |
| 41 | Dániel Sallói |  Toronto | 8 | |
| 41 | Jorge Ruvalcaba | Red Bull NY | 8 | |
| 41 | Kristoffer Velde | Portland | 8 | |
| 41 | Mateusz Bogusz | Houston | 8 | 2 |
| 41 | Marco Reus | LA Galaxy | 8 | 3 |
| 47 | André Luiz | Kansas City | 7 | |
| 47 | Cavan Sullivan | Philadelphia | 7 | |
| 47 | Josh Sargent | Toronto | 7 | |
| 47 | Marcus Caldeira | Minnesota | 7 |
Contados de los partidos jugados del torneo en curso (los goles en contra no suman).